Research Article

Correlation of dyslipidemia and athrogenic index of plasma with anthropometric measurements and clinical variables among diabetic patients in Dessie Comprehensive Specialized Hospital, Ethiopia, 2021

Mekuriaw Wuhib, Belachew Tegegne*, Leul Mekonnen, Zemen Mengesha, Mitaw Girma, Mamo Solomon and Getachew Wuhib

Published: 14 July, 2022 | Volume 6 - Issue 1 | Pages: 025-033

Background: Control of increased athrogenic index of plasma and lipid parameters in the early stage of diabetes mellitus helps diabetic patients to improve their quality of life and treatment outcomes. Limited studies were conducted on the assessment of dyslipidemia and its correlation with clinical and anthropometric variables among diabetes patients but no study was conducted on the correlation of the athrogenic index of plasma with anthropometric measurements among diabetes patients in this study area. The objective of this study was to assess the correlation of dyslipidemia and athrogenic index of plasma with anthropometric measurements and clinical variables among diabetic patients in Dessie Compressive specialized hospital, Northeast Ethiopia.
Methods: Institution-based comparative cross-sectional study was conducted from August 2020 to June 2021. A total of 250 diabetic and healthy control respondents were included in the study with convenience sampling. Semi-structured questionnaire of a modified WHO stepwise Approach to Surveillance for chronic disease was used to collect data. Finally, descriptive statistics and correlation analysis were conducted to assess the correlation between variables. A P-value of less than 0.05 was declared as the level of significance.
Results: Athrogenic Index of Plasma, Triglyceride to High-density Lipoprotein Ratio, Very-Low-Density Lipoprotein, systolic blood pressure, diastolic blood pressure, triglyceride, waist circumference, WHtR and BMI were statistically significantly higher among type 2 DM groups. There was a significant positive linear correlation between triglycerides and waist circumference, between TG / HDL and WHtR, and between cholesterol and WHtR, but a significant negative linear correlation between HDL and waist circumference among the Type 2 DM group. Systolic blood pressure and pulse showed a significant positive linear correlation with WC, BMI, and WHtR among diabetics groups only. Our study showed that the pattern of lipid abnormalities observed among DM patients was high AIP in 68%, moderate AIP in 16% and all four groups of hyperlipidemia were found in 9% of diabetic patients. All lipid profiles showed a significant very strong positive linear correlation with AIP, but DHL has a significant very strong negative linear correlation with AIP among type 2 DM groups.
Conclusion: The proportions of high athrogenic index of plasma and lipid profile disorders were higher in DM patients compared to healthy controls. Dyslipidemia and a high athrogenic index of plasma had a considerable correlation with anthropometric measurements and clinical outcomes of type II DM patients. DM patients who have a higher athrogenic index of plasma and higher lipid parameters should be strictly followed based on their anthropometric measurements.

Read Full Article HTML DOI: 10.29328/journal.acgh.1001035 Cite this Article Read Full Article PDF


Anthropometric measurements; Athrogenic index of plasma; Correlation; Diabetes mellitus; Dyslipidemia and Ethiopia


  1. Marathe PH, Gao HX, Close KL. American D iabetes A ssociation S tandards of M edical C are in D iabetes 2017. Wiley Online Library; 2017.
  2. Seino Y. The committee of the japan diabetes society on the diagnostic criteria of diabetes mellitus: report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Invest. 2010;1:212-28.
  3. Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis. 2014 Dec 6;13:183. doi: 10.1186/1476-511X-13-183. PMID: 25481115; PMCID: PMC4271485.
  4. Wakil S. Lipid metabolism: Elsevier; 2012.
  5. Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. New England Journal of Medicine. 2010;362(9):800-11.
  6. Uttra KM, Devrajani BR, Shah SZA, Devrajani T, Das T, Raza S, et al. Lipid profile of patients with diabetes mellitus (A multidisciplinary study). World Appl Sci J. 2011;12(9):1382-4.
  7. Akdoğan M, Ustundag-Budak Y, Huysal K. The association of hematologic inflammatory markers with atherogenic index in type 2 diabetic retinopathy patients. Clinical Ophthalmology (Auckland, NZ). 2016;10:1797.
  8. Ahmad SI. Diabetes: an old disease, a new insight: Springer Science & Business Media; 2013.
  9. Cui R, Qi Z, Zhou L, Li Z, Li Q, Zhang J. Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus. Clin Interv Aging. 2016 Apr 18;11:445-52. doi: 10.2147/CIA.S104803. PMID: 27143868; PMCID: PMC4841420.
  10. Chehrei A, Sadrnia S, Keshteli AH, Daneshmand MA, Rezaei J. Correlation of dyslipidemia with waist to height ratio, waist circumference, and body mass index in Iranian adults. Asia Pac J Clin Nutr. 2007;16(2):248-53. PMID: 17468079.
  11. Nimmanapalli HD, Kasi AD, Devapatla P, Nuttakki V. Lipid ratios, atherogenic coefficient and atherogenic index of plasma as parameters in assessing cardiovascular risk in type 2 diabetes mellitus. Int J Res Med Sci. 2016;4(7):2863-9.
  12. Bhardwaj S, Bhattacharjee J, Bhatnagar M, Tyagi S, Delhi N. Atherogenic index of plasma, castelli risk index and atherogenic coefficient-new parameters in assessing cardiovascular risk. Int J Pharm Biol Sci. 2013;3(3):359-64.
  13. Dobiasˇova M. Atherogenic index of plasma [log (triglycerides/HDL-cholesterol)]: theoretical and practical implications. Oxford University Press; 2004.
  14. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, Abrishami M, Juya M, Khodaee G, Dadgarmoghaddam M. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran. 2015 Jul 25;29:240. PMID: 26793631; PMCID: PMC4715400.
  15. Biadgo B, Abebe SM, Baynes HW, Yesuf M, Alemu A, Abebe M. Correlation between Serum Lipid Profile with Anthropometric and Clinical Variables in Patients with Type 2 Diabetes Mellitus. Ethiop J Health Sci. 2017 May;27(3):215-226. doi: 10.4314/ejhs.v27i3.3. PMID: 29217920; PMCID: PMC5614992.
  16. Farid SM. Study of correlation between anthropometric parameters (BMI, WC, WHR) and atherogenic index of plasma (AIP) in type 2 diabetics in Jeddah, Saudi Arabia. GJBB. 2018;7:60-9.
  17. Organization WH. WHO STEPS instrument (core and expanded). Geneva, Switzerland: WHO URL: http://www who int/chp/steps/STEPS_Instrument_v2. 2015;1.
  18. Chen Y, Zhang X, Pan B, Jin X, Yao H, Chen B, Zou Y, Ge J, Chen H. A modified formula for calculating low-density lipoprotein cholesterol values. Lipids Health Dis. 2010 May 21;9:52. doi: 10.1186/1476-511X-9-52. PMID: 20487572; PMCID: PMC2890624.
  19. Wilson PW, Abbott RD, Garrison RJ, Castelli WP. Estimation of very-low-density lipoprotein cholesterol from data on triglyceride concentration in plasma. Clin Chem. 1981 Dec;27(12):2008-10. PMID: 6946880.
  20. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama. 2001;285(19):2486-97.
  21. Ozden C, Ozdal OL, Urgancioglu G, Koyuncu H, Gokkaya S, Memis A. The correlation between metabolic syndrome and prostatic growth in patients with benign prostatic hyperplasia. Eur Urol. 2007 Jan;51(1):199-203; discussion 204-6. doi: 10.1016/j.eururo.2006.05.040. Epub 2006 Jun 14. PMID: 16806666.
  22. Bo MS, Cheah WL, Lwin S, Moe Nwe T, Win TT, Aung M. Understanding the Relationship between Atherogenic Index of Plasma and Cardiovascular Disease Risk Factors among Staff of an University in Malaysia. J Nutr Metab. 2018 Jul 4;2018:7027624. doi: 10.1155/2018/7027624. PMID: 30116641; PMCID: PMC6079547.
  23. Federation ID. IDF diabetes atlas 8th edition. International Diabetes Federation. 2017:905-11.
  24. Walelgne W, Yadeta D, Feleke Y, Kebede T. Guidelines on Clinical and Programmatic Management of Major Non Communicable Diseases. Addis Ababa: Federal Democratic Republic of Ethiopia Ministry of Health. 2016.
  25. Shao J, Yu L, Shen X, Li D, Wang K. Waist-to-height ratio, an optimal predictor for obesity and metabolic syndrome in Chinese adults. J Nutr Health Aging. 2010 Nov;14(9):782-5. doi: 10.1007/s12603-010-0106-x. PMID: 21085910.
  26. Haile K, Timerga A. Dyslipidemia and Its Associated Risk Factors Among Adult Type-2 Diabetic Patients at Jimma University Medical Center, Jimma, Southwest Ethiopia. Diabetes Metab Syndr Obes. 2020 Nov 26;13:4589-4597. doi: 10.2147/DMSO.S283171. PMID: 33273834; PMCID: PMC7705268.
  27. Al-Ajlan AR. Lipid Profile in Relation to Anthropometric Measurements among College Male Students in Riyadh, Saudi Arabia: A Cross-Sectional Study. Int J Biomed Sci. 2011 Jun;7(2):112-9. PMID: 23675226; PMCID: PMC3614826.
  28. Thakur K, Singh MM, Jaswal R, Sharma KK. Correlation between anthropometric indices and dyslipidemia in T2DM: CHD risk assessment and identification of Metabolic Syndrome.
  29. Okpa HO, Enang OE, Effa EE, Essien OE, Mbu PN. Comparative analysis of atherogenic index of plasma and its relationship with cardiovascular risk among patients with diabetes mellitus and concurrent diabetes mellitus with hypertension attending endocrinology clinic in a tertiary hospital south-south Nigeria. atherosclerosis. 2015;13(15):16.
  30. Onat A, Can G, Kaya H, Hergenç G. “Atherogenic index of plasma”(log10 triglyceride/high-density lipoprotein− cholesterol) predicts high blood pressure, diabetes, and vascular events. Journal of clinical lipidology. 2010;4(2):89-98.
  31. Tadesse F, Worku Y, Feleke Y, El-Metwally T. Metabolic syndrome biomarkers in type ii diabetic Ethiopian patients. J Metabolic Synd. 2014;3(1000139):2167-0943.1000139.
  32. He S, Wang S, Chen X, Jiang L, Peng Y, Li L, Wan L, Cui K. Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population. Metabolism. 2012 Jan;61(1):30-6. doi: 10.1016/j.metabol.2011.05.007. Epub 2011 Jun 12. PMID: 21664631.
  33. Jain V, Yadav SS, Jain J. Metabolic syndrome in type 2 diabetes, an anthropometric and biochemical evaluation--A cross-sectional study from Central India. International Journal of Medical Science and Public Health. 2018;7(10):784-90.
  34. Sufa B, Abebe G, Cheneke W. Dyslipidemia and associated factors among women using hormonal contraceptives in Harar town, Eastern Ethiopia. BMC Res Notes. 2019 Mar 4;12(1):120. doi: 10.1186/s13104-019-4148-9. PMID: 30832721; PMCID: PMC6399905.
  35. Tan MH, Johns D, Glazer NB. Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes. Clin Chem. 2004 Jul;50(7):1184-8. doi: 10.1373/clinchem.2004.031757. Epub 2004 Apr 29. PMID: 15117857.
  36. William B, Riaz I, Mubashir S, Aslam K, Saeed A, Anjum I. Dyslipidemia as a risk factor for developing hypertension and cardiovascular disease in females of reproductive age. J Nat Appl Sci Pak. 2019;1(2):139-47.
  37. Fernández-Macías JC, Ochoa-Martínez AC, Varela-Silva JA, Pérez-Maldonado IN. Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses. Arch Med Res. 2019 Jul;50(5):285-294. doi: 10.1016/j.arcmed.2019.08.009. Epub 2019 Oct 5. PMID: 31593853.


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