Abstract

Research Article

The influence of Infliximab on the development of Experimental Pancreatitis

Lychkova AE*, Golubev Yu Yu and Puzikov AM

Published: 25 August, 2017 | Volume 1 - Issue 1 | Pages: 007-011

Aim: To identify the possibility of correction of motor function of the gastro-intestinal tract in experimental pancreatitis with the administration of infliximab.

Material and methods: Pancreatitis was modeled by the administration of picrylsulfonic acid retrogradely into the pancreatic duct of rat (n=5) and 4 animals were control. Electromyogram (EMG) of the pancreatic duct was monitored immediately after the administration of picrylsulfonic acid and on the 15th day of pancreatitis simulation before and after the administration of infliximab. The morphological investigation of pancreas was conducted on the 15th day of development of pancreatitis and on the 15th day of treatment of pancreatitis with infliximab.

Results: Infliximab restores the motor function of pancreatic duct and structure of pancreas during acute pancreatitis.

Conclusion: Protective action of infliximab during acute pancreatitis was shown.

Read Full Article HTML DOI: 10.29328/journal.hcg.1001003 Cite this Article Read Full Article PDF

Keywords:

Rat; Pancreatic duct; Motor function; Pancreatitis; Infliximab

References

  1. Schäfer C, Tietz AB, Göke B. Pathophysiology of acute experimental pancreatitis: lessons from genetically engineered animal models and new molecular approaches. Digestion.2005; 71: 162-172. Ref.: https://goo.gl/JWEVUq
  2. Lee JU, Shin W, Son JY, Yoo KY, Heo YS. Molecular Basis for the Neutralization of Tumor Necrosis Factor α by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases. Int J Mol Sci. 2017; 18: 228. Ref.: https://goo.gl/x4GARQ
  3. Ou X, Cheng Z, Liu T, Tang Z, Huang W, et al. Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis. Pancreas. 2015; 44: 1089-1095. Ref.: https://goo.gl/sDEabp
  4. Fantini L, Tomassetti P, Pezzilli R. Management of acute pancreatitis: current knowledge and future perspectives. World J Emerg Surg. 2006; 23: 1-16. Ref.: https://goo.gl/BrDMia
  5. Ozhan G, Yanar HT, Ertekin C, Alpertunga B. Polymorphisms in tumor necrosis factor alpha (TNFalpha) gene in patients with acute pancreatitis. Mediators Inflamm. 2010; 2010: 482950. Ref.: https://goo.gl/h2ekXm
  6. Maev IV, Kucheryavy Yu A. Drug therapy for chronic pancreatitis. News of medicine and pharmacy. 2007; 218: 14-16.

 

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