Abstract

Case Report

A Rare Case of Cytomegalovirus Colitis Mimicking Colon Adenocarcinoma in an Immunocompetent Patient

Khalid Al-Rayess*, Matthew Glover and Ameer Khalek

Published: 11 July, 2025 | Volume 9 - Issue 1 | Pages: 013-014

Cytomegalovirus (CMV) colitis is classically seen in immunocompromised individuals, such as those with HIV, organ transplants, or receiving immunosuppressive therapy. It is exceedingly rare in immunocompetent patients and can pose a diagnostic challenge, especially when it presents as a mass-like lesion mimicking colon cancer. We report a case of a 78-year-old immunocompetent male who presented with hematochezia and was found to have a bleeding cecal mass initially suspicious for adenocarcinoma. Subsequent histopathology revealed CMV colitis. This case emphasizes the importance of considering CMV colitis in the differential diagnosis of colonic masses, even in immunocompetent hosts.

Read Full Article HTML DOI: 10.29328/journal.acgh.1001051 Cite this Article Read Full Article PDF

Keywords:

Cytomegalovirus (CMV); CMV colitis; Immunocompetent; Colon adenocarcinoma; Histopathology; Differential diagnosis; Antiviral therapy; Colonic mass; Cecal mass; Ganciclovir; Valganciclovir; Inclusion bodies; Mass-like lesion

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